9/1/2023 0 Comments Nutrfs![]() ![]() Immuno-oncology in 2019: the rapid evolution continues The cells were gene-edited to lack PD-1, the immune checkpoint targeted by drugs such as Merck &Co’s Keytruda (pembrolizumab) and Bristol-Myers Squibb’s Opdivo (nivolumab), and the impact of Opdivo plus Yervoy on OS in first-line NSCLC patients’.Ģ019: CRISPR and therapeutic gene editing comes of age In June 2018, Bristol Myers-Squibb sought approval for Opdivo and low-dose Yervoy in lung cancer in patients with a TMB of greater than ten mutations per megabase. Opdivo is being squeezed out of the market by Merck &Co/ The merger was completed shortly after BMS reported the first decline in quarterly sales of its immuno-oncology blockbuster Opdivo (nivolumab) since its launch five years ago, and 2020 is viewed. Merck Sharp &Dohme (MSD), the company that markets Keytruda, and Bristol-Myers Squibb (BMS), the company that markets Opdivo, approached development of their respective products in this area with starkly contrasting Putting commercial intelligence at the heart of strategy CheckMate-76K was a randomised, double-blind study which The study showed that Opdivo reduced the risk of recurrenceīristol Myers Squibb (BMS) has announced positive results from a phase 3 trial evaluating Opdivo (nivolumab) as a single agent in the adjuvant setting in patients with completely resected stage. By attaching to PD-1, Opdivo blocks its action and allows the body’sīristol Myers Squibb’s Opdivo shows promise as adjuvant melanoma treatmentīristol Myers Squibb (BMS) has announced positive results from a phase 3 trial evaluating Opdivo (nivolumab) as an adjuvant therapy in patients with completely resected stage 2B/C melanoma. Opdivo is a targeted immunotherapy designed to recognise and attach to a specific protein called programmed death-1 receptor (PD-1), which can shut off the body’s immune system. of the Cabometyx and Opdivo combinationīristol Myers Squibb’s Opdivo recommended by NICE for rare gastroesophageal cancers Opdivo is currently approved in more than 65 countries, including the US, EU, Japan and China for a range of indications such as melanoma,īMS, Exelixis and Ipsen report three-year results for combination treatment in kidney cancerīristol Myers Squibb (BMS), Exelixis and Ipsen have reported positive three-year follow-up results from a phase 3 study of Opdivo (nivolumab) in combination with Cabometyx (cabozantinib) in advanced renal. For instance, Windows uses NTFS, while Macs require internal storage devices to be formatted in Mac OS Extended File System or HFS+.BMS reports positive three-year results for Opdivo to treat bladder cancerĬells expressed PD-L1 of 1% and over, median NUTRFS was 52.6 months with Opdivo versus 8.4 months with placebo. File systems keep everything tidy and minimize loss of storage space by logically organizing data.ĭifferent operating systems use different file systems. When you store something, be it a movie or a video game, on a storage device, the computer knows where the file will go thanks to the file system. This is exactly what file systems do for your data. You know the organization so well that whenever you bring home a new shirt, you know where to put it in your closet. There is a certain place for shirts, a place for shoes, and a place for trousers. In a closet, there are different compartments for different things. To understand file systems better, imagine you have a well-organized closet. They are pieces of software that help an OS organize data and use space more efficiently. ![]() What Are File Systems?įile systems represent how data is stored on a storage device. Read on to learn about file systems in more detail, and see which file systems are best for Windows 10. ![]()
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9/1/2023 0 Comments Epic mountain express cupons![]() ![]() You’ll need high-quality gear, too, which is why you also get 20 off ski and snowboard rentals with your Epic Pass. So calling a person and specifically asking for the free under-four epic pass is what worked. Take 20 off group ski lessons and take your skills on the slopes to the next level. Exclusions: Intenta Con Uno Invalido Primero, Dara Error. So the price they show, $165, is literally impossible to receive! Has anyone ever gotten their epic discount on kids ski school group lessons?ĮDIT: I was able to receive the discount by directly calling Vail and setting up my daughter with a free Under Four epic pass! This wasn't something that the website said I could do and when I did a "live chat" online the person had no idea, just said getting the discount was impossible. 15 Off Epic Mountain Express Code (Unverified): Get 15 Off Airport Transportation Between June 1 - Octoat Show Promo Code 617 uses Last used 1wk ago Unverified Code 10 Off Epic Mountain Express Promo Code (Unverified): Extra 10 Off Airport Shuttles. Included with every pass at no additional charge, Epic Coverage provides. Epic Mountain Express Promo Code: Get an Extra 15 Off (Airport Transportation Between June 1. Epic Mountain Rewards: Included with every pass, Epic Mountain Rewards gets you 20 off food, lodging, equipment rentals, group lessons, Epic Mountain Express, and even heli-skiing Epic Coverage: If something unexpected happens, weve got you covered. When I go to the booking page, they show the discount price that reflects my Epic pass, but when I try to book them, I have to select my child who will be taking the class as the "traveler," and since SHE doesn't have an epic pass, I don't get the discount! I can't select myself as the traveler, since I'm not four years old, and it's impossible for a four year old to have an epic pass, because they ski free. This code gives customers 35 off at Epic Mountain Express. It's of great benefit for you to to save your budget at Epic Mountain Express. ![]() I feel like this must be a mistake, but it seems that "Epic Mountain Rewards" on ski school lessons - 20% off $207 - are not actually possible to receive. 11.18 Average Savings Get Epic Mountain Express Employee Discounts, Offers, & Promotions Customers shouldn't wait to grab this amazing deal - Get Epic Mountain Express Employee Discounts, Offers, & Promotions within its validity. ![]() ![]() ![]() ![]() Just remember: Not all vacuum sealer bags are compatible with all machines, so double check the model's specifications first. And if you plan to sous vide, make sure you get boil-safe bags or rolls. ✔️Type of bags: If you need different sized bags for different tasks, consider buying rolls instead of pre-cut bags, since you can size these bags to fit your needs. Do you need something straightforward and intuitive for simple tasks, like freezing occasional cuts of meat or leftovers? Or, do you need a do-it-all workhorse that's also designed for sous vide? Keep in mind, you can use these gadgets for practically anything: In addition to things like poultry, beef and fish, you can also seal dry goods (flour, sugar, pasta, cookies and even coffee beans), as well as fruits, veggies, cheese and pre-cooked meals like soups and stews. ✔️Functions: Before buying a vacuum sealer, think about your needs. ![]() Most can also re-seal bags, like potato chip and cereal bags. They're more versatile and provide longer-lasting results since there's nowhere for the air to escape or let other air in. Countertop models are larger and can often use both pre-cut and cut-to-size bags.They're less effective at keeping air out, though. Handheld models typically use Ziploc-style bags that have a small port for air removal, ideal for small jobs and meal prep.countertop: If you lack space or tend to move around a lot, you'll likely prefer the maneuverability of a handheld machine, but if you rely on your food vacuum sealer often, the superior performance and durability of a countertop model may suit you better. 19.99 Box Sets - From 39.99 Bag Sets - From 26.99 It’s time to increase your storage space The ultimate vacuum seal storage bags for clothes, coats, bedding and more, Spacesaver helps you declutter your home, maximize luggage space and protect your favorite linens. The best vacuum sealers are slim and can do it all (seal both dry foods and liquids, as well as pulse and seal), but it's worth considering the following factors when looking to buy: If you are looking for more kitchen gadgets to add to your collection, check out our roundup of the best food dehydrators. Scroll to the bottom of this article for more information on how we test vacuum sealers. Both handheld and countertop vacuum sealers can help all kinds of food last longer (except for foods like soft cheeses, raw mushrooms and fresh garlic that contain anaerobic bacteria, which loves oxygen-free zones).įor decades, the Good Housekeeping Institute Kitchen Appliances and Innovation Lab has researched and evaluated all kinds of kitchen products, including ones that can help you keep your food fresh for longer, from the best food storage containers to top reusable produce bags. The tight seal also helps prevent moisture loss and freezer burn. Vacuum sealers work by removing air from a plastic bag filled with food before sealing it with heat, keeping your food fresher for longer by creating an environment that makes it very hard for bacteria to thrive. ![]() ![]() ![]() One transistor circuit configuration which can be used to quite a good effect in many instances is the Darlington Pair. The Darlington Pair transistor configuration of two bipolar transistors offers growth current switching for a given base.
![]() ![]() Veterinarians frequently choose to use an IV because it allows for convenient administration of any extra medications that may be required during the course of the treatment. This will necessitate the administration of anti-seizure medications through needle injection or an IV. ![]() Your cat’s immediate life-threatening symptoms must first be stabilized by your veterinarian. The typical symptoms of flamingo flower poisoning that you should be aware of are:įirst Aid and Treatment of Flamingo Flower Poisoning in Cats Clinical Signs of Flamingo Flower Poisoning in CatsĪ variety of ailments may develop due to the ingestion of the flamingo flower plant. Newer cultivars are less fussy about humidity, and many hybrids are more lush, compact, and will bloom nearly year-round, taking a break in the winter. Many hybrids are more lush, compact, and will bloom nearly year-round, taking a break in the winter. ![]() Bright light, moist soil, and moist air are preferred by this Central American native. Anthurium grows well in warm, tropical climates. The tall flower stems are surrounded by large pointed dark-green leaves that grow up to seven inches long. Costa Rica’s tropical climate is home to this species. Prevention of Flamingo Flower Poisoning in Catsįlamingo Flower or scientifically known as anthurium scherzeranum is a bright red and yellow houseplant with lovely green leaves.Recovery from Flamingo Flower Poisoning in Cats.First Aid and Treatment of Flamingo Flower Poisoning in Cats.Clinical Signs of Flamingo Flower Poisoning in Cats.If your cat does ingest large quantities of the compound despite the painful affects and taste, the chemicals cause organ damage and, eventually, failure. These can cause your cat’s airways to swell as an inflammatory reaction to the injury. Irritation from exposure to the compounds will cause ulcers in your cat’s mouth, throat, and stomach. The reaction to these compounds is immediate and so severe that, fortunately, most cats are deterred from eating much of the plant and not exposed to large quantities of the poison. Flamingo flower contains a compound that is toxic to your cat, known as insoluble calcium oxalates. Lack of consciousness from blocked airwayĬauses of Flamingo Flower Poisoning in Catsįlamingo flower poisoning occurs when your cat chews or ingests any portion of the flamingo flower plant.Shaking of head or other signs of mouth pain or irritation.Symptoms of flamingo flower poisoning in your cat include: While even a small amount can cause irritation and discomfort, due to its nearly instant effect, most cats will not ingest the toxic chemicals of the plant in large quantities. Symptoms of Flamingo Flower Poisoning in Catsįlamingo flower causes a variety of severe symptoms in your cat. If you suspect your cat is suffering from poisoning resulting from ingesting flamingo flower you should seek veterinary assistance immediately. You should avoid having flamingo flower in your home if you have cats that are prone to chewing on household flowers. In severe cases, your cat may face life-threatening conditions as a result of flamingo flower poisoning. While these plants are attractive for humans, when eaten by your cat, they can be extremely harmful and will cause a great deal of pain and discomfort for your pet. Timothy Allen 11 MAR 2016 – 29 MAR 2017įFlamingo flowers are popular evergreen house plants that produce long lasting flowers, typically red with yellow stems, and drooping glossy foliage.Christina (Christy) Marie Exchange Student. ![]() 9/1/2023 0 Comments Past minecraft server files![]() ![]() How Long Does It Take to Set Up a Minecraft Server? It also contains a step-by-step guide for creating a Minecraft server on your PC. Fortunately, our how-to guide uses Hostinger’s Minecraft game servers as an example. Not difficult at all! The challenge comes from fiddling with services or tasks you aren’t familiar with, which can be daunting at a glance. How Difficult Is It to Set Up a Minecraft Server? If you’re hosting on your own PC, you need Minecraft Java Edition, as well as some command line knowledge. If using a web host, you simply need the cash to purchase and maintain the servers for the task. Besides that, consider whether you want to host via a dedicated web hosting service, or through your own PC. You need an internet connection, first and foremost. What Do You Need to Set Up a Minecraft Server? If you're interested in creating a Minecraft server, we'll walk you through what you need to know. A web hosting service removes most of the set up and work required to manage a server, but radically ups the cost. ![]() Sure, there is a wealth of online resources, but if you aren’t particularly tech savvy, this can result in a lot of work. To top it all off, you must figure out and resolve any issues that crop up with your server. Other apps running on your PC can affect your hosting capabilities, too. A poor connection can result in a lag-filled gameplay experience. However, the quality of your home internet connection directly impacts how other people connect with your server. When hosting your own Minecraft server, you save money by not paying a web hosting service, and you have complete server control-assuming you know what you’re doing. There are strengths and challenges with both approaches. What’s more, many web hosts offer customer support, so if you are hesitant about setting up a server by yourself, the additional help will set your mind at ease. If you don’t mind paying for the service, this is a solid option. Many web hosting services offer dedicated Minecraft-oriented hosting that streamlines the entire process. Both require a modicum of technical know-how, but the VPS route is generally much easier. You can choose to pay a virtual private server (VPS) provider to host your Minecraft server, or you can host the server on your own computer. There are a few ways to go about creating a Minecraft server, but there are two major avenues you can take. Best Hosted Endpoint Protection and Security Software. ![]() 9/1/2023 0 Comments Crimson applejack hat![]() Apple Bloom shares her talent at carpentry, art and design with Toola Roola's G3/G3.5 counterpart Toola-Roola, who later became one of the Core 7 ponies. Īpple Bloom shares her color scheme with several previous-generation ponies: Candy Apples' G3 counterpart Candy Apple, another Earth pony G3 Earth pony Sunshimmer, who resembles Sunset Shimmer Sunburst's G1 Earth pony counterpart, a Mountain Boy Pony and G3/G3.5 Fiesta Flair, an Earth pony who was only featured in the direct-to-video productions. She's a little spitfire, but not a tomboy she needs energy and presence, but enough range to play the sensitive parts." The script consists of two scenes, one each from Applebuck Season and Griffon the Brush Off, with Apple Bloom in place of Spike. She should sound as authentic of a child as possible. An audition script that uses Gilda's original name, Grizelda, lists Apple Bloom's age as seven and gives her the description "Apple Bloom is an 'every girl'. Many characters before Blossom have had it." Minutes later, she was further asked, "so the CMC-PPG comparisons are just coincidence?" and answered, "I was aware of the similarity, but it wasn't a purposeful nod to PPG (or Kiki's Delivery Service, either.)" Blossom of the Powerpuff Girls-not to be confused with G1 Earth pony Blossom-and Kiki's Delivery Service have since been referenced in the respective forms of Friends Forever 16 Unnamed Filly - Blossom and My Little Pony: Friendship is Magic Issue #30 cover RI. Big red bows on young girls is a old visual icon. Intentional or serendipitous?" and answered, "Neither, really. During a question-and-answer session on Twitter regarding season one, Faust was asked, "So. ![]() She was named Appleseed, but the name ran into some copyright issues, leading to the current name. ![]() Apple Bloom was designed by Lauren Faust for her "pitch bible" for the show in 2008. ![]() Apple Bloom is one of the founding members of the Cutie Mark Crusaders, a club/"secret" society devoted to helping ponies earn their cutie marks, along with Sweetie Belle and Scootaloo. She is varyingly called Apple Blossom and Apple Boom in some other media and promotional material.įoals such as Apple Bloom were inspired by Ember's G1 Earth pony counterpart. She is the younger sister of Applejack and Big McIntosh and granddaughter of Granny Smith. Gabriela Milani ( Brazilian Portuguese, season 4)Īnnie Rojas ( Latin American Spanish, seasons 2-3)Īpple Bloom is a female school-age Earth pony and a member of the Apple family. Mônica Toniolo ( Brazilian Portuguese, season 1)Ĭidália Castro ( Brazilian Portuguese, S3E4)Īndressa Andreatto ( Brazilian Portuguese, S3E8) Marie Christin Morgenstern ( German, S6E4 only) Yelyzaveta Zinovenko ( Ukrainian, season 5 onward) Natalya Romanko ( Ukrainian, seasons 1-4) Susana Moreno ( Latin American Spanish, from S1E9 onward) Isabella Guarnieri ( Brazilian Portuguese) Joanna Pach-Żbikowska ( Polish, seasons 1-3, S6E19-S7E16, S9E10 onwards) Nur Azeera Nazir ( Malaysian, seasons 4-5) Wang Yanhua ( Chinese for mainland China) (some merchandise and some promotional material) īrittany Lauda ( English, My Little Pony: Fluttershy's Famous Stare) School of Friendship tutor ( S8E12-S9E26)ĪB, Half Pint, Gabby Gums, Squirt, Junebug, Apple Boot, Ap ( The Periodic Table of My Little Pony) Apple Bloom as an adult in Growing Up is Hard to Do ![]() 9/1/2023 0 Comments Tomb raider 1![]() ![]() Product Quote “MINI EPICS let us breathe new life into much-loved characters… then give them an unexpected twist! They are a sculptor’s dream. Capturing that spirit of adventure and endless bravery, our Mini Epics team have crafted the world’s foremost adventurer into a world-class collectible. Product Description (flavour text) Both are deadly, both are dangerous, and both are experts in their field, but this raptor may have bitten off more than it can chew. Tomb Raider (Clone) iso for Playstation (PSX/PS1) and play Tomb Raider (Clone) on your devices. Product Intro Many forgotten dangers lurk deep with The Lost Valley, but Lara Croft is up for the challenge. Stock Quantity in China Warehouse ETA: Q2 2023 Item Name Mini Epics - Lara Croft & Raptor Quote author Mauro Santini – Mini Epics Art Director, Wētā Workshop Product Quote “MINI EPICS let us breathe new life into much-loved characters… then give them an unexpected twist! They are a sculptor’s dream.” ![]() These pint-sized figures have BIG personalities." ![]() That knowing sparkle in those eyes – you didn’t think it got there by accident, do you? Tilt your head a little to the left and you might just catch a wink.Įndlessly collectible. This cast of miniaturised characters was created by Wētā Workshop’s collectible team, a dedicated crew of artists, technicians, craftspeople, and producers, all relishing the chance to distil oodles of personality into an EPIC package. Each piece is painted by hand and slight variations will occur.Ībout this product "SUPER-STYLISED AND ULTRA-EXPRESSIVE Images are of a pre-production prototype. Product Disclaimer Please note: This product was designed and prototyped at Wētā Workshop. Sculpted by Wētā Workshop’s Mini Epics Art Director, Mauro Santini." Depending on if youre playing this game on a physical console or an emulator will determine how you use the codes found on this page. Tomb Raider is a classic adventure/action game released in 1996. Product Description (flavour text) Whether it’s venturing deep into the jungle or trekking through the desert, Lara has the tools and knowledge to survive and thrive. Tomb Raider (Version 1.1) CodeBreaker/Gameshark Codes (NTSC-U) This page contains CodeBreaker/Gameshark cheat codes for Tomb Raider for the Playstation 1. Product Intro No trap too dangerous, no riddle too hard no treasure is safe from this Mini Epic! Wētā Workshop Studio/Brand intro Mini Epics pay homage to your favourite characters, distilling their unique personalities into stylised vinyl figures worthy of your shelf. Con le sue forze, ma non da sola, ha un solo obiettivo sa raggiungere: sopravvivere. (without packaging)" 3.93" x 6.73" x 1.61" (W x H x D) 10 cm x 17.1 cm x 4.1 cm Dopo che una brutale tempesta distrugge limbarcazione su cui stava viaggiando, una giovane donna, spaventata, naufraga su una spiaggia sconosciuta. It's not like I ever really ran out of medipacks and ammo in the EU version anyway so I like the endless collectibles.Įnemies in TR3 JP have same health like enemies in International version (only Tony has double health (200 HP) in TR3 JP instead 100 HP).Intellectual Property/License Tomb Raider ![]() I enjoy playing the JP version, it's like an arrange mode. Once you go in that little area with the shells, it comes at you, but it spawns at the same time it does in the EU version. For example, the second tiger in Jungle does not jump out and attack you because it's stuck behind a brick wall with a big opening that has replaced the ferns. If anything there's a couple more because of the map changes. Not sure if there's any bug-fixes per se. There are minor changes to the maps, making puzzle solutions and hidden areas slightly more obvious, but not actually easier to complete/get into. The crystals function as a 100% health boost, and there are more of them, in line with the other pickups. I purchased Tomb Raider 3 PSX JP version and it has about double the pickups, an infinite save crystal in your inventory, Japanese text and speech, and enemies have half the health. ![]() 9/1/2023 0 Comments Enbrel copay card renewal![]() ![]() If I cancel my consent, I will no longer qualify for the services described. I understand that I can obtain a copy of this Authorization or cancel this Authorization at any time by calling Amgen SupportPlus at 1-833-44AMGEN (1-83) or by writing to PO BOX 2135, Morristown, NJ 07962-9927. Signing below, I am authorizing those who rely on thisĪuthorization to release my personal health information for theĮarlier of five (5) years or until my participation in the programĮnds through my cancellation, unless a shorter time period is Information, including my personal health information, to be usedįor the purposes described above. I also understand I am authorizing my personal Release it to Amgen employees, as well as to its contractors andīusiness partners, who are performing the services set forth in Providers or others who might hold my health information to only I understand that by signing this form, I authorize my Health Care Personal health information and/or for using my information toĬontact me with communications about Amgen products which haveīeen prescribed to me (for example medication reminder programs)Įxpiration, Right to Obtain a Copy and Right to Cancel Receive remuneration from Amgen in exchange for disclosing my Providers (such as pharmacies and specialty pharmacies) may I understand that certain of my Health Care Health information to Amgen, and between themselves,Īs necessary, but only for the purposes stated above in thisĪuthorization. I authorize my Health Care Providers to disclose my personal My health care plan benefits, payment limits or restrictionsĬovered by my health care plan policy, and/or my adherence to my Information from or about my medical history and general health, Pharmacy, pharmaceutical company, laboratory and/or theirĬontractor (“Health Care Provider”). ![]() Of or derived from a health care provider, health care plan, Information, in electronic or physical form, in the possession I understand that my personal health information may include any Information, including my personal health information. In order for Amgen to provide me with the services and/or programsĭescribed above, Amgen needs to collect and use my personal Materials and programs related to my condition or treatment. To improve, develop, and evaluate products, services,.Relating to Amgen products and services, and/or my condition To provide me with informational and promotional materials.Health care team and share with them my health information that To contact, with my permission, my doctor and the rest of my.Verification, nurse educator services, adherence program and Programs, reimbursement assistance programs, drug coverage Related to my condition or treatment (for example, co-pay Participation in Amgen ® SupportPlus program or any otherĪmgen-affiliated patient support services and activities To operate, administer, enroll me in, and/or continue my ![]() Including my personal health information, only for the following (“Amgen”) to use and/or disclose my personal information, I authorize Amgen and its contractors and business partners Uses and Disclosure of Personal Information ![]() ![]() ![]() If you’re in the mood for a delicious, hearty meal that will satisfy your inner child, look no further than Dino Nuggets! These nuggets are made with real chicken and are oven-baked to perfection. ![]() You’ll know the nuggets are done when they’re golden brown and cooked through.Įnjoy your delicious Dino Nuggets! How to Cook Dino Nuggets in Oven Keep an eye on your food as it cooks and adjust the time accordingly. If you’re using fresh chicken nuggets, they will only need about 8 minutes in the air fryer. In general, you should plan on cooking frozen chicken nuggets for about 10 minutes at 400 degrees Fahrenheit. For example, frozen chicken nuggets will take longer to cook than fresh chicken nuggets. The cooking time will vary depending on the size and thickness of your food. When it comes to air frying, there is no one-size-fits-all answer. So if you’re looking for a quick, easy and healthy way to cook frozen dino nuggets, give air frying a try! Plus, air fried food tends to be more crisp and flavorful than its deep-fried counterpart. This cooking method also cuts down on prep time and cleanup since there’s no need to heat up a large pot of oil. When finished, remove the cooked nuggets from the basket and serve with your favorite dipping sauce.Īir frying is a healthier alternative to deep frying because it uses less oil. Shake or flip the basket halfway through cooking to ensure even browning. ![]() Then, place the frozen nuggets in the basket of the air fryer and cook for 10 minutes. To cook frozen dino nuggets in an air fryer, start by preheating the appliance to 400 degrees Fahrenheit. Here’s what you need to know about air frying frozen dino nuggets. This cooking method is a quick and easy way to get a crispy, tasty meal on the table. The answer is yes, you can cook frozen dino nuggets in an air fryer. Tyson Fun Nuggets Air Fryer Instructions.How Do You Cook Frozen Dino Chicken Nuggets?.How Long Do You Cook Frozen Nuggets in an Air Fryer?. ![]() |
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